Linus Pauling--Molecular Diseases, Sickle Cell Anemia

Sickle cell anemia is a serious condition in which the red blood cells can become sickle-shaped (that is, shaped like a "C").

Normal red blood cells are smooth and round like a doughnut without a hole. They move easily through blood vessels to carry oxygen to all parts of the body. Sickle-shaped cells don't move easily through blood. They're stiff and sticky and tend to form clumps and get stuck in blood vessels.

The clumps of sickle cells block blood flow in the blood vessels that lead to the limbs and organs. Blocked blood vessels can cause pain, serious infections, and organ damage. http://www.nhlbi.nih.gov/health/dci/Diseases/Sca/SCA_WhatIs.html

Clinical trial to test vitamin C against non-Hodgkin lymphoma

Researchers at Thomas Jefferson University Hospital and the Kimmel Cancer Center in Philadelphia, in collaboration with the National Institutes of Health, are initiating a trial to test the effects of high dose vitamin C in patients with non-Hodgkin's lymphoma (NHL). The study will be the first to test the effects of the vitamin when administered intravenously to NHL patients.

A team led by Daniel Monti, MD, who is the director of the Myrna Brind Center of Integrative Medicine at Thomas Jefferson, plans to enroll twenty patients for whom standard non-Hodgkin lymphoma therapy has been unsuccessful. Trial participants will receive varying doses of intravenous vitamin C three times per week while being monitored for disease progression. Continue Reading

Time to take on time

To significantly reduce disease, we must slow the aging process, according to a team of experts who published their conclusion online in the British Medical Journal on July 8. In an article entitled, “New model of health promotion and disease prevention for the 21st century,” Professor S. Jay Olshansky of the University of Illinois at Chicago and his associates suggest that the current focus on preventing and curing individual diseases will become outmoded as people in developed countries live longer and develop the multiple chronic illnesses that come with aging.
“The change in strategy we are calling for requires a systematic attack on aging itself,” they write. “Evidence in models ranging from invertebrates to mammals suggests that all living things, including humans, possess biochemical mechanisms that influence how quickly we age and that they are adjustable.” Due to a greater life expectancy in developed countries, the increased incidence of diseases related to aging has resulted in a dramatic rise in health care costs. Dr Olshansky and colleagues note that if an extended life span is combined with health, it could result in a number of economic, social, and other benefits, which they call “the longevity dividend.” They propose increased funding for studies that will increase our knowledge concerning the relationship of aging to such diseases as type 2 diabetes, Parkinson's disease, and most cancers, in addition to research into the processes that control aging itself. Continue Reading

Some genetic defects treatable with supplements

An article published early online on June 3, 2008 in the Proceedings of the National Academy of Sciences reports the prediction of Jasper Rine and colleagues at the University of California, Berkeley that soon-to-be-available personalized genome sequencing will uncover minor genetic flaws that can easily be corrected with nutrition, enabling people to personalize their supplement routine.

"Headlines for the last 20 years have really been about the triumph of biomedical research in finding disease genes, which is biologically interesting, genetically important and frightening to people who get this information," Dr Rine. "I became obsessed with trying to decide if there is some other class of information that will make people want to look at their genome sequence."Variations in genes responsible for the production of enzymes involved in metabolism affect the efficiency of these enzymes.

While having two copies of a defective gene can result in one of many rare metabolic diseases that can be treated with vitamin supplements, many individuals have only one copy, or have two copies of only slightly defective genes, whose subtle effects on enzymes, Dr Rine’s team found, could also be remedied by vitamin supplementation. The current study examined one human enzyme, methylenetetrahydrofolate reductase (MTHFR), which requires the B vitamin folate to function properly.

The enzyme plays a role in DNA nucleotide synthesis. Among 564 individuals, 3 common variants and 11 minor, uncommon genetic variants of MTHFR were found. When these gene variants were synthesized and inserted into yeast cells, the most common variant and 4 of the uncommon variants were found to affect the enzyme's function, yet supplementation of the yeast with folate restored full functionality to all but one of these. Continue Reading

When Oxidants Can Increase Risk of Death

1. When Antioxidants Can Increase Risk of DeathThe truth about these nutrients - their benefits and risks

Antioxidants have long been considered good news, helping to reduce the 'oxidative' damage caused by everyday living that ages and eventually kills us. We are encouraged to eat foods (especially our 'five a day') that provide rich sources of antioxidant nutrients, and a massive market for antioxidant supplements has sprung up with literally thousands of studies to affirm their benefits.

But in the last few years, a number of big trials have apparently shown that taking extra antioxidants in the form of supplements doesn't work. They have reported that antioxidants, far from staving off the big killers such as cancer and heart disease, can actually make them worse. A recent review of a number of studies gave rise to media headlines such as "Antioxidants can kill".

So what is going on?
After numerous studies that showed extra antioxidants reduced risk of disease, some more recent research started to look at their effect on two particular 'at-risk' groups - people who smoked and those with cardiovascular disease.

Several of these trials showed that the risk of cancer in smokers increased slightly when they were given beta-carotene. Other studies suggested a small increased risk of heart attack in heart patients who were on medications such as statins and taking vitamin E.
What's interesting to note, however, is that far from putting the nail in the coffin of antioxidants, these studies give us an interesting insight into how these nutrients work - and why people who smoke or take statins are at risk, unless they adapt (rather than stop) their supplement intake.
For example, the recent Cochrane Review by Bjelakovic et al actually found that people who took BOTH multivitamin AND antioxidant supplements showed no increased risk, and in some cases, a significant decrease in risk. Now why should that be, and what does it tell us about the way antioxidants work?

I believe it points to a simple explanation as to why high-dose vitamin E increases cardiovascular risk, why beta-carotene increases smokers' risk, and why multivitamins eradicate this risk.
With this month's 100%health newsletter, I have produced a Special Report which looks in detail as these issues.

Find out:
. Why statins make high-dose vitamin E dangerous
. The nutrients that can reduce disease risk for smokers
. Why the Cochrane review is flawed
. The reactions to the review's findings from scientists whose studies were included
. The positive findings that went unreported
. And most importantly, what you can do to protect yourself - whether you're taking statins or smoking, are elderly or young, in good health or bad.

Click here to make sure you receive your copy.
My July newsletter also tackles the controversial issue of Childhood Vaccinations and looks at the evidence behind the guidelines so many parents are questioning.
I'll also be exploring the latest research into anti-ageing to bring you the best tips to help you turn the clock back and stay youthful.

And there's another Special Report on the plant compounds Salvestrols - a new discovery that could provide a major breakthrough in the prevention and treatment of cancer.
To ensure you receive all this - plus a whole range of exclusive member benefits - click here to join 100%health.

2. Two days is all it takes to change your life. Book now to qualify for Early Bird discounts
Learn how to build up your energy, control your weight and beat nagging problems that plague your health.

Our ever popular 100%health Weekend Workshop will give you manageable tools to combat the obstacles in your life that are holding you back. All you need is the desire and determination to transform your life. We do the rest by tailor-making a new life plan for you.

The next workshop is on 27th/28th September in London and I will spend two days taking you through a step-by-step guide to the eight key areas that will lead you to optimum health including information on the best foods to eat, why eating low-GL is best, cookery demonstrations and a personalised Health Action Plan. Plus a follow-up online health assessment to help you track your progress.

What you'll achieve
By the end of the weekend you will know exactly what you need to do to achieve the boundless energy, sharp mind, balanced mood, stable weight and glowing skin that are the hallmark of great health. We give you the tools to do it and the confidence to follow it through.
Book today and take the first step. I very much hope you will join me on the next 100%health Workshop in London on 27th/28th September. Places strictly limited - book your ticket now to qualify for the Early Bird discount of £50! Click here for more details and how to book.
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3. Are you interested in becoming a nutritional therapist?
The Institute for Optimum Nutrition offers a 3-year part time foundation science degree in nutritional therapy.

If you are interested in studying nutrition to qualify as a nutritional therapist , the Institute for Optimum Nutrition have asked me to let you know there are still some places available on their excellent course commencing this September. To find out more book your place on one of the remaining open days see the ION website for more details: http://www.ion.ac.uk/open_days.htm
Wishing you the best of health,
Patrick Holford

Cocoa flavanols improve blood vessel function in diabetics

The June 3, 2008 issue of the Journal of the American College of Cardiology published the results of a first-of-its kind study which showed that consuming cocoa flavanols improved vascular function in patients being treated for type 2 diabetes.

Vascular dysfunction occurs early in the development of cardiovascular disease, which is a common killer of diabetic individuals. Even when diabetes is medically treated and “controlled,“ vascular dysfunction often persists. In an initial study, Malte Kelm, MD, and colleagues at University Hospital RWTH Aachen in Germany gave 10 diabetic adults a drink containing 75, 371 or 963 milligrams cocoa flavanols.

Plasma flavanol metabolite levels and flow mediated dilation of the brachial artery (which assesses vascular health by evaluating the ability of the artery to relax) were monitored for several hours following flavanol administration.The researchers determined that improvements in flow mediated dilation correlated with increased flavanol dose.

A double-blinded trial was then conducted in which 41 patients undergoing medical treatment for type 2 diabetes were given a beverage containing 25 milligrams or 321 milligrams cocoa flavanols three times daily for thirty days. The beverages were matched for calories and other cocoa compounds such as caffeine. Flow-mediated dilation and flavanol metabolite levels were measured before treatment, 2 hours after the initial treatment, at 8 days, and at 30 days. Continue Reading

Niacin (Vitamin B3) Lowers High Cholesterol Safely

OMNS - There is a safe, inexpensive, nonprescription, convenient and effective way to reduce high cholesterol levels and reduce heart disease risk: niacin. Niacin is a water-soluble B-complex vitamin, vitamin B-3. One of niacin's unique properties is its ability to help you naturally relax and to fall asleep more rapidly at night. It is well established that niacin helps reduce harmful cholesterol levels in the bloodstream. Niacin is one of the best substances for elevating high density lipoprotein cholesterol (the "good cholesterol) and so decreases the ratio of the total cholesterol over high density cholesterol.

The finding that niacin lowered cholesterol was soon confirmed by Parsons, Achor, Berge, McKenzie and Barker (1956) and Parsons (1961, 1961a, 1962) at the Mayo Clinic, which launched niacin on its way as a hypocholesterolemic substance. Since then it has been found to be a normalizing agent, meaning it elevates high density lipoprotein cholesterol, decreases low density and very low density lipoprotein cholesterol and lowers triglycerides. Grundy, Mok, Zechs and Berman (1981) found it lowered cholesterol by 22 percent and triglycerides by 52 percent and wrote, "To our knowledge, no other single agent has such potential for lowering both cholesterol and triglycerides."

Elevated cholesterol levels are associated with increased risk of developing coronary disease. In addition to niacin, a typical diet generally recommended by orthomolecular physicians will tend to keep cholesterol levels down in most people. This diet can be described as a high fiber, sugar-free diet which is rich in complex polysaccharides such as vegetables and whole grains.

With adequately high doses of niacin, it is possible to lower cholesterol levels even with no alteration in diet. E. Boyle, then working with the National Institutes of Health in Washington, D.C., quickly became interested in niacin. He began to follow a series of patients using 3 grams (3,000 milligrams) of niacin per day. He reported his conclusions in a document prepared for physicians involved in Alcoholics Anonymous by Bill W (1968). In this report, Boyle reported that he had kept 160 coronary patients on niacin for ten years. Only six died, against a statistical expectation that 62 would have died with conventional care. He stated, "From the strictly medical viewpoint I believe all patients taking niacin would survive longer and enjoy life much more." His prediction came true when the National Coronary Drug Study was evaluated by Canner recently. But Boyle's data spoke for itself. Continuous use of niacin will decrease mortality and prolong life. Continue reading >>

VITAMIN C KILLS CANCER CELLS

Intravenous Vitamin C is Selectively Toxic to Cancer Cells
(OMNS) National Institutes of Health scientists have confirmed the concepts that vitamin C is selectively toxic to cancer cells and that tumor-toxic levels of vitamin C can be attained using intravenous administration. The article, published in the September 12, 2005 issue of the Proceedings of the National Academy of Sciences (1) concluded, “These findings give plausibility to intravenous ascorbic acid in cancer treatment.”

Orthomolecular medical researchers, including Nobel laureate Linus Pauling, have long recognized the great importance of vitamin C in fighting cancer. (2) Scientists associated with the Bio-Communications Research Institute (BRCI) in Wichita, Kansas have published 20 scientific articles on the subject. (3) BCRI researchers first reported in 1995 that vitamin C in sufficient amounts is selectively toxic to tumor cells. The authors concluded that tumor-toxic levels of vitamin C could be achieved only by giving the vitamin intravenously. Subsequent research from BCRI, published in the British Journal of Cancer in 2001 (4), was the first to describe in detail the pharmacokinetics of high doses of intravenous vitamin C.

"It is gratifying to have our research on vitamin C and cancer confirmed by scientists at the prestigious National Institutes of Health," said Neil Riordan, Ph.D., BCRI’s Research Director. “The findings reinforce our goal and commitment to pursue cutting edge cancer research,” added Michael Gonzalez, Ph.D., D.Sc. of the University of Puerto Rico.

BCRI’s vitamin C research was headed by its founder Hugh D. Riordan, M.D. The research team includes Dr. Xiaolong Meng, Dr. Joseph Casciari, Dr. Nina Mikirova, Dr. Jie Zhong, Dr. James A. Jackson, Dr. Don Davis, Dr. Jorge Miranda, Dr. Michael Gonzalez, Dr. Neil Riordan, and Mr. Paul Taylor.

What is Orthomolecular Medicine?
Linus Pauling defined orthomolecular medicine as "the treatment of disease by the provision of the optimum molecular environment, especially the optimum concentrations of substances normally present in the human body." Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org/

Continue reading >>

HIGH-DOSE VITAMIN C FIGHTS ASTHMA

(OMNS) People with severe asthma have low blood concentrations of ascorbate (vitamin C), particularly men [1] and children [2].

Effective asthma treatment is readily available with cheap, safe and convenient vitamin C. The only requirement is to take enough vitamin C to be effective. Typical dietary quantities and low supplemental doses do not work. Robert F. Cathcart III, M.D., who has treated many asthma sufferers, says “Asthma is most often relieved by bowel tolerance doses of ascorbate (vitamin C). A child regularly having asthmatic attacks following exercise is usually relieved of these attacks by large doses of ascorbate. So far all of my patients having asthmatic attacks associated with the onset of viral diseases have been ameliorated by this treatment.”[3]

If you want asthma relief, consider trying this:

Go to a discount store and buy a large bottle of 1,000 mg vitamin C tablets. The cost should be less than $15.

Beginning when you awake in the morning, take 1,000 to 2,000 mg of vitamin C every 30 minutes and continue doing so until you have a single episode of loose stool (not quite diarrhea). If you haven’t had loose stool after 15 hours on this dosage, increase the vitamin C to 3000 mg every 30 minutes.

After you have a loose bowel movement, reduce the dosage to 2,000 mg of vitamin C every hour. You will quickly find the dosage that is right for you. Adjust the dosage of vitamin C downward to stay below the dosage that will cause loose stool and adjust it upward to relieve asthma symptoms. The usual maintenance dosage to remain asthma-free is 15,000 to 50,000 mg of vitamin C per day taken in eight equally divided doses.

People with asthma should also avoid tobacco smoke, minimize stress in their lives and minimize their consumption of junk foods, meat and dairy products.

Remember:
Vitamin C replaces antibiotics, antihistamines, antipyretics, antitoxics, and antiviral drugs at saturation (bowel tolerance) levels. It reduces inflammation.

A vitamin can act as a drug, but a drug can never act as a vitamin. Continue reading >>

Doctors Report Vitamin C Cures Shingles

OMNS - Shingles can be cleared up by using a safe, convenient, inexpensive, nonprescription treatment of vitamin C. Vitamin C is anti-viral and anti-toxin and inactivates the virus that causes shingles. If you have shingles and want relief, you can try this:

Go to a discount store and buy a large bottle of 1000 mg vitamin C tablets. The cost should be less than $15.

Begin when you wake in the morning by taking 3000 mg of vitamin C every 30 minutes and continue until you have a single episode of loose stool (not quite diarrhea). If you haven't had loose stool after 15 hours on this dosage, increase the vitamin C to 4000 mg every 30 minutes.

After you have a loose bowel movement, reduce the dosage to 2000 mg of vitamin C taken every hour. You will quickly find the dosage that is right for you. Adjust the dosage of vitamin C downward to stay below the dosage that will cause loose stool and adjust it upward to relieve shingles symptoms. Continue the oral vitamin C therapy until the shingles disappear.

It sounds too simple to be true, doesn't it? But it works in the majority of cases, as recently reconfirmed by Thomas E. Levy, M.D., J.D. (1)

Sometimes it's necessary to take vitamin C intravenously (IV) for massive shingles outbreaks. (2) Much higher concentrations of vitamin C in the blood can be achieved intravenously than when taken orally. As early as 1950, the medical literature reported that one physician had confirmed intravenous vitamin C curing shingles in 327 patients within 72 hours. (3) Ask your doctor if he or she offers vitamin C IV and, if not, ask friends or search the Internet to find a doctor or facility that does offer this treatment.

Vitamin C blood serum levels of individuals fall during periods of high stress and they develop sub-clinical scurvy (depleted vitamin C levels). This situation can set the stage for a shingles attack.

Remember, a vitamin can act as a drug, but a drug can never act as a vitamin.
With vitamin therapy, at any given quantity, frequently divided doses are more effective than one large single dose.

The reason one nutrient can cure so many different illnesses is because a deficiency of one nutrient can cause many different illnesses.

What is Orthomolecular Medicine? Continue reading >>

Narrator: A person afflicted with the disease has inherited two sickle cell genes from his parents. This realization, that the two genes manufacture the abnormal hemoglobin, set the stage for Dr. Pauling's entry into the field of molecular medicine.

Dr. Pauling: Well, when Doctors Itano, Singer, and Wells, and I published our paper in 1949, we gave it the title: "Sickle Cell Anemia: A Molecular Disease." Now of course, in fact, one might say that any inborn error of metabolism, any hereditary disease, is a molecular disease because it involves an abnormal gene. And the gene we know, almost certainly, is a molecule of DNA, deoxyribose nucleic acid.

The abnormal molecule of deoxyribose nucleic acid that is inherited by the child, prospective patient, causes the trouble for him, and the hereditary disease is accordingly a molecular disease.

NOBEL PRIZE WINNER AND SEVEN OTHER GIANTS OF MEDICINE INDUCTED INTO THE ORTHOMOLECULAR MEDICINE HALL OF FAME

(Toronto, May 14, 2005) Eight giants in the field of medicine, who were advocates of the use of nutrition in the treatment of cancer, were inducted in the Orthomolecular Medicine Hall of Fame on May 14, 2005 at a special reception held at the Fairmont Château Laurier in Ottawa, Canada.

The annual induction ceremony is one of the highlights at The International Society for Orthomolecular Medicine (ISOM) 34th Annual International Conference, Nutritional Medicine Today, which this year met in Canada's capital and at which leading physicians and scientists from around the world gather to discuss ground-breaking studies in nutritional medicine, cardiovascular disease, oncology and mental health.

All inductees, whose seminal work has been influential in the medical and scientific worlds, are pioneers in their respective fields and include the Nobel Prize winner who discovered vitamin C, and numerous advocates of Vitamin C Therapy especially with respect to cancer treatment. The 2005 inductees are: Emanuel Cheraskin, MD, DMD; Max Gerson, MD; David Horrobin, MD, PhD; Josef Issels, MD; Frederick Klenner, MD; Cornelius Moerman, MD; Hugh Desaix Riordan, MD and Nobel Prize Winner Albert Szent-Gyorgi, PhD.

Although they have now passed away, their contributions to the betterment of mankind have been significant and will live long after them. Members of their families and colleagues were on hand to join in the acknowledgment and celebration of their life's work.

Dr. Cheraskin, who, for decades, headed the Department of Oral Medicine at the School of Dentistry at the University of Alabama was among the very first to recognize and demonstrate that oral health indicates total body health.

Dr. Horrobin was Medical Adviser and President of the Schizophrenia Association of Great Britain and his study of human physiology lead him to investigate the role of fatty acids and their derivatives in human disease and to investigate the therapeutic potential of lipids in medicine.

Dr. Max Gerson, began observing that cancer could be cured with nutrition in tandem with systemic detoxification. Albert Schweitzer stated that Dr. Gerson was one of the most eminent geniuses in medical history, while Prince Charles who knew of a terminally ill patient who had undergone Gerson Therapy and is alive and well remarked that "rather than dismissing such experiences, we should further investigate the beneficial nature of these treatments."

Dr. Issels also believed that good nutrition and a clean environment were central to his cancer therapy and felt that cancer was the ultimate symptom of a lifetime of immune system damage which had created an environment for a tumor to grow while conventional therapy just looked at the tumor without recognizing this longtime preconditioning period.

Dr. Klenner asserted that vitamin C is the safest substance available to the physician and was the first doctor to emphasize that small amounts of ascorbic acid do not work and that only adequate uses and huge doses of vitamin C will provide results.

Dr. Moerman's name remains symbolic in the Netherlands as a leader in nutritional therapy for the treatment of cancer as he also believed that strengthening the immune system by proper nutrition was the answer to this disease.

Dr. Hugh Riordan was the first to demonstrate how large doses of vitamin C are chemotherapeutic for cancer patients and his vitamin C intravenous chemotherapy studies are being continued at the University of Kansas and at McGill University in Montreal.

Albert Szent-Gyorgyi, PhD, won the 1937 Nobel Prize in Medicine for his discovery of vitamin C. In fact, it was he who named the vitamin ascorbic acid and first predicted its use in cancer treatment.

Last year, the first inductees to the Orthomolecular Medicine Hall of Fame included double Nobel Prize laureate LINUS PAULING, PhD; WILLIAM KAUFMAN, MD, PhD; WILLIAM J. McCORMICK, MD; EVAN SHUTE MD and WILFRID SHUTE, MD; ALAN COTT, MD; HUMPHRY OSMOND, MD; CARL PFEIFFER, MD, PhD; IRWIN STONE and ROGER J. WILLIAMS, PhD. Continue Reading >>

MOST DIETS NEED SUPPLEMENTATION - Even "Good" Ones

Most illness is due fundamentally to malnutrition. This not only includes the chronic diseases, but also viral and bacterial acute illnesses, which are greatly aggravated by inadequate nutrition. The usual US diet provides an insufficient amount of vitamins to maintain optimal health. And the evidence base for the clinical effects of vitamins is increasing rapidly.

Only 3 percent of a large sampling of U.S. adults practices what is commonly considered a healthy lifestyle. An American Medical Association survey of 153,000 men and women between the ages of 18 and 74 found that only 23.3 percent reported consuming five servings of fruits and vegetables per day. [1] New federal nutritional guidelines specify a minimum of nine servings of fruits and vegetables per day. [2] Many Americans find that consuming the minimum quantities of fruits and vegetables each day is impractical, and appear unable to provide the needed nutrition for themselves and their families. An alternative is to eat all the fruits and vegetables possible, and supplement with a multivitamin/multi-mineral, 400 IU of vitamin E and 1000 mg of vitamin C. [3] A better alternative is to supplement twice a day after meals.

The usual U.S. diet provides an insufficient amount of vitamins. [4] Yet decades of scientific evidence has shown that vitamins, especially vitamin C and vitamin E, are of the utmost importance to human health.

Two-time Nobel Prize winner Dr. Linus Pauling was among the first to realize vitamin C's crucial importance in the maintenance of a healthy immune system. In 1970 he proposed that regular intake of vitamin-C in amounts far higher than the Recommended Daily Allowance (RDA) could help prevent and shorten the duration of the common cold. Although the medical establishment immediately voiced their strong opposition to this idea, many ordinary people believed Dr. Pauling and began taking large amounts of vitamin-C. Most people immediately noticed a great decrease in the frequency and severity of their colds. [5] Continue Reading >>

Vitamin C Fights Heart Disease

Millions die each year from heart disease and stroke, and the overwhelming evidence is that vitamin C supplementation would save many lives.

Two-time Nobel Prize winner Dr. Linus Pauling estimated that the rate of heart disease would be reduced by 80 per cent if adults in the US supplemented with 2,000 to 3,000 mg of vitamin C each day. According to Dr. Pauling, "Since vitamin C deficiency is the common cause of human heart disease, vitamin C supplementation is the universal treatment for this disease."[1] Heart disease is the number one killer in the US. For those with existing heart disease Dr. Pauling said that blockage of heart arteries could actually be reversed by supplementing with 6,000 of vitamin C and 6,000 of lysine (a common amino acid) taken in divided doses throughout the day. Vitamin C supplementation both lowers serum cholesterol levels and repairs lesions of arterial walls. 1998 Nobel Prize winner Dr. Louis J. Ignarro found that supplementing with vitamin C and vitamin E significantly reduces the risk of developing arteriosclerosis.[2]

A study examined vitamin E and vitamin C supplement use in relation to mortality risk in 11,178 persons aged 67-105 who participated in the Established Populations for Epidemiologic Studies of the Elderly over a nine year period.[3] Simultaneous use of vitamins E and C was associated with a lower risk of total mortality and coronary mortality after adjusting for alcohol use, smoking history, aspirin use, and medical conditions.

A landmark study following over 85,000 nurses over a 16-year period for a total of 1,240,000 person-years found that vitamin C supplementation significantly reduced the risk of heart disease.[4] Intake of vitamin C from foods alone was insufficient to significantly effect the rate of heart disease. High quantities of vitamin C from supplements was essential to provide the protective effects. The study adjusted for age, smoking, and a variety of other coronary risk factors.

An international team pooled data from nine prospective studies of 293,000 people that included information on intakes of vitamin E, carotenoids, and vitamin C, with a 10-year follow-up to check for major incident coronary heart disease events in people without disease when the study began. Dietary intake of antioxidant vitamins was only weakly related to a reduced coronary heart disease risk. However, subjects who took as little as 700 mg of vitamin C daily in supplement form reduced their risk of heart disease events by 25 per cent compared to those who took no supplements. [5] Read the full story>>

Vitamin E: Safe, Effective, and Heart-Healthy

Heart disease is the number one killer in the United States, and the evidence supporting vitamin E's efficacy in preventing and reversing heart disease is overwhelming.

Two landmark studies published in the New England Journal of Medicine [1][2] followed a total of 125,000 men and women health care professionals for a total of 839,000 person study-years. It was found that those who supplement with at least 100 IU of vitamin E daily reduced their risk of heart disease by 59 to 66%.

The studies were adjusted for life-style differences (smoking, physical activity, dietary fiber intake, aspirin use) in order to determine the heart effect of vitamin E supplementation alone. Because a diet high in foods containing vitamin E as compared to the average diet further showed only a slight heart-protective effect, the authors emphasized the necessity of vitamin E supplementation.

Researchers at Cambridge University [3] in England reported that patients who had been diagnosed with coronary arteriosclerosis could lower their risk of having a heart attack by 77% by supplementing with 400 IU to 800 IU per day of the natural (d-alpha tocopherol) form of vitamin E.

Pioneer vitamin E researchers and clinicians Drs. Wilfrid and Evan Shute treated some 30,000 patients over several decades and found that people in average health received maximum benefit from 800 IU of the d-alpha tocopherol form of vitamin E. Vitamin E has been proven effective in the prevention and treatment of many heart conditions. "The complete or nearly complete prevention of angina attacks is the usual and expected result of treatment with alpha tocopherol" according to Wilfrid Shute, M. D., a cardiologist. Shute prescribed up to 1,600 IU of vitamin E daily and successfully treated patients for acute coronary thrombosis, acute rheumatic fever, chronic rheumatic heart disease, hypertensive heart disease, diabetes mellitus, acute and chronic nephritis, and even burns, plastic surgery and mazoplasia. Read the full story>>

Study Shows Vitamin "Pill-Poppers" Are Healthier

(OMNS November 2, 2007) New research indicates that NOT taking supplements may be harmful to your health, and that a single daily multi-vitamin is inadequate.

A study of hundreds of persons who take a number of different dietary supplements has found that the more supplements they take, the better their health is.

The study authors reported that a "greater degree of supplement use was associated with more favorable concentrations of serum homocysteine, C-reactive protein, high-density lipoprotein cholesterol, and triglycerides, as well as lower risk of prevalent elevated blood pressure and diabetes." Supplement use results in higher levels of nutrients in the blood serum, and produces "optimal concentrations of chronic disease-related biomarkers." [1] Read the full story>>

JOURNAL OF ORTHOMOLECULAR MEDICINE NOW ONLINE

(OMNS February 29, 2008) The archives of the Journal of Orthomolecular Medicine are now posted online. Past issues from 1967 through 2002 are available for downloading, at no charge, at http://orthomolecular.org/library/jom/index.shtml

"36 years of important material is now freely available to everyone," said Steven J. Carter, Executive Director of the Toronto-based International Schizophrenia Foundation, which publishes the Journal.

The Journal of Orthomolecular Medicine has led the way in presenting, in advance of other medical journals, new health concerns and treatments including niacin therapy for schizophrenia and coronary disease; vitamin C for cancer; and the nutritional treatment of behavioral disorders, and drug and alcohol abuse. The JOM was also the first medical journal to publish papers on the nutritional treatment of allergies, autism, and AIDS. JOM published pioneering research on candiasis in 1978, mercury amalgam toxicity in 1982, and chronic fatigue syndrome in 1988. The Journal has published over 100 papers on nutritional medicine and cancer, and over 400 articles on schizophrenia and other psychiatric illnesses. JOM is peer-reviewed.

The Journal was founded in 1967 as the Journal of Schizophrenia, and subsequently titled the Journal of Orthomolecular Psychiatry until 1986. Nobel Laureate Linus Pauling authored 9 papers in the Journal from 1970-1992. It was Pauling that gave nutritional medicine the name "orthomolecular." Says JOM Editor-in Chief Abram Hoffer, MD, PhD: "In 1968, Dr. Pauling proposed the term orthomolecular (1,2) which we recognized as the correct word to define the total interest in nutrition, clinical ecology, and the use of vitamin and mineral supplements. All the pioneers in orthomolecular medicine have reported their findings in this journal. It thus represents a unique source for these earlier and current studies which provide a basis for the increasing growth of nutritional medicine." Continue the full article >>

Vitamin Supplementation Prevents Anorexia

(OMNS February 9, 2008) Anorexia is primarily due to vitamin deficiency. Approximately one in twenty teenage girls in America is struggling with an eating disorder. Parents can help eliminate the risk of anorexia by providing their children with vitamin supplements.

Anorexia is an acknowledged clinical marker of beriberi, the disease specifically caused by a deficiency of vitamin B1 (thiamine). [1] Anorexia is also commonly observed as an early symptom of pellagra (niacin deficiency) [2] and is a known complication of scurvy, vitamin C deficiency. [3] Prevention is especially important, because beriberi/anorexia often does not respond well even to treatment with high doses of thiamine for months, and sometimes does not respond at all. [1] But as a rule, high potency vitamin supplements are an effective cure for the loss of muscle mass caused by beriberi and the skin lesions caused by pellagra.

The vitamin B1 in almost every multivitamin and B-complex vitamin pill is either thiamine mononitrate or thiamine hydrochloride. The body’s ability to absorb these two forms of thiamine is limited [4] by the maximum amount that can be handled by the body’s two specialized thiamine transport proteins. [5]. This means many doses per day of oral thiamine are necessary for effective treatment. Another class of thiamine molecules, called allithiamines, are much better absorbed. [6] Since allithiamines are not included in standard multivitamin preparations, we recommend their reformulation to include this specific form of B1.

The conventional medical approach to eating disorders such as anorexia typically includes psychological/behavioral treatment, medication, and food-groups dietetics. It is surprisingly rare for physicians to link eating disorders with vitamin deficiency, and few doctors recommend vitamin supplements for prevention. Continue the full article

Vitamin C and dairy linked to less abdominal weight

An increased intake of vitamin C and dairy could reduce the accumulation of weight around the abdomen, reported to increase the risk of diabetes and heart disease, suggests a new study.

Over 900 Iranian women aged between 40 and 60 years were found to have more central fat accumulation if their intakes of vitamin C, calcium, and dairy are low.

Indeed, low vitamin C intake was associated with a 131 per cent increase in probability of central fat accumulation, while low calcium increased the probability by 30 per cent.

The study, published in the journal Public Health Nutrition, looks set to continue the debate about whether dairy foods can promote weight loss, and what the mechanism behind such an effect could be.

Leila Azadbakht and Ahmad Esmaillzadeh from Isfahan University of Medical Sciences used a semi-quantitative food-frequency questionnaire (FFQ) to evaluate dietary intakes.

They report that the possibility of being centrally obese was increased in women with low vitamin C intakes (less than 56 milligrams), low calcium intakes (less than 398 mg), and low dairy consumption.

Others factors found to adversely affect weight around the waist were depression, smoking and menopausal state.

In terms of the mechanism or mechanisms behind the apparent benefits of the nutrients, the researchers state that both the vitamin and calcium have been reported to reduce fat absorption and may reduce abdominal adiposity.

"The mechanism by which milk consumption affects obesity indices is not accurately known. Most studies have cited calcium as a responsible factor. So, an inverse relationship has been suggested between calcium intake and body weight and body fat mass in various ways. Its simple effect is the inhibition of fat and fatty acid absorption," they stated.


"However, this is not the major cause; it seems that the major effect of calcium on body weight is mediated by its effects on controlling intracellular calcium," they added.

A previous study from Purdue University claimed that young women could burn more calories if they ate three or four dairy servings per day. However another report, also from Purdue, reported that increased dairy consumption had no effect on weight gain or loss.

On the other hand, Dr. Michael Zemel from the University of Tennessee told attendees at last year's Paris Anti-Obesity Therapies 2006 conference that dairy can help reduce body fat and that calcium only accounts for about 40 per cent of the effect.

Dairy industries in Europe and the US have been promoting milk-based products for consumers who want to slim for some time but the new findings underline that further work needs to be done to support such claims.

A diet low in dairy foods has been linked to an increased risk of accumulating fat

Indeed, the results have been welcomed by the UK-based Dairy Council. The council's director Dr. Judith Bryans said: "These results are exciting, as a number of other scientific studies have also suggested a possible link between regular consumption of low fat dairy foods and weight loss, particularly from the waist area.

"This study simply highlights the importance of a healthy lifestyle including plenty of physical and mental activity, and a diet that incorporates a good balance of all food groups, including dairy," she said.

Source: Public Health Nutrition
Doi: 10.1017/S1368980007000882
"Dietary and non-dietary determinants of central adiposity among Tehrani women"
Authors: L. Azadbakht and A. Esmaillzadeh

CURING ALCOHOLISM NATURALLY

Dr. Carolyn Dean, MD, ND and
Elissa Meininger
November 17, 2005
NewsWithViews.com

One of the most satisfying things about the natural healing arts is that when you are thoroughly committed to its principles, you discover a contentment you can never find in modern medicine. Natural healing is about making people whole. It’s about arranging all the elements of your life to be as supportive as possible in all ways so that when you pass from this life, you do so at peace with yourself and the world around you. It’s not about fighting off the evils of disease or postponing the grim reaper no matter what the cost. And it certainly isn’t about diagnosing some disease and declaring yourself a victim of that disease, a label you must carry through life like a scarlet letter branded on your forehead.

The worst part of having a drinking problem is giving the behavior a name with the implication that once you have been branded an alcoholic, the next unspoken thought is “always an alcoholic”. Softening this branding by claiming those who have stopped drinking are “recovering” alcoholics, is just sliding into another form of discrimination, believing that we are nothing more the diseases we suffer and are life-long victims.

The plain fact of the matter is that all of us have issues that involve emotional, spiritual and physical components. We all need to establish the parameters of how we shall live out our lives. Those of us who want to maximize our lives learn to wrestle with, in a positive manner, those issues which make life less than perfect. To claim that we are all victims of disease or victims of situations that scar us for life is about feeling sorry for ourselves and not embracing life to the fullest.

A good example of how not to fall into this trap is something my NewsWithViews.com writing partner, Elissa, experienced. She was so poisoned by mercury from her dental amalgams, she was in pain for months on end, trying to detox it from her system. Pain killers were out of the question, and when her spirits were particularly low, she’d muster what little sense of humor she had, call her naturopath and say, “Skip the rest of the herbs, send the hemlock”. In return, knowing that she was at the end of her rope emotionally, he, being a true blue naturopath of the best kind, would ask her, “What is the gift?” This was a signal for her to embrace her suffering so she could fully examine the lessons pain and suffering could teach her about the value of life, the learning of patience, and other deeply spiritual issues, so that when the suffering was over, she would be a much wiser person, more ready to really live life to the fullest.

How many of us have known people who have suffered a great deal and have become incredibly wonderful people? How many of us have taken the trouble to surround ourselves with a positive support system and how many of us have arranged to have good things come our way because we have become positive thinkers and doers? These are all important issues that when we are caught in the throws of suffering, might be worth thinking about.

When I suggested to Elissa that we provide information from my colleagues in Orthomolecular Medicine about how they successfully treat alcoholism through nutrition, Elissa quickly pointed out that having been trained in Transactional Analysis back in the 1970’s, she was well aware that TA practitioners were not into naming diseases, either, and, in fact, didn’t consider alcoholism a disease at all.

Created by Eric Berne, MD, Transactional Analysis is a system of analyzing people’s patterns of behavior. It became the first of several therapeutic models that is particularly adaptable to self-help by lay people. Central to its core philosophy is that the client has the capacity to change and that the teacher-therapist is largely there to assist the client in taking charge of his/her own healing. In allopathic psychiatry and similar therapies, the therapist’s role is to diagnose a “disease” and be the authority figure who helps the “patient” become more well adjusted, though rarely healed.

When it was introduced in the 1960’s, TA revolutionized our understanding of what really goes on during our most basic social interactions. Best selling books such as “Games People Play”, “I’m OK, You’re OK”, “Success Through Transactional Analysis”, and “Born to Win” were on everyone’s coffee tables and the concepts of TA was quickly adopted into common usage. Everyone was analyzing “games”, discussing “life-scripts”, giving and receiving positive “strokes” and making jokes about who was more “OK” than somebody else.

Back then Elissa would have been delighted to add to her TA knowledge information about nutritional approaches that support the health of people who’d been trashed out by too much alcohol. She pointed out that to a TA counselor, the goal is to teach the client about the principles and practical methods of clarifying true emotions, develop useful information about how to run you own life, clean up old baggage from the past without going on what she calls an archeological expedition to rehash how much you hate your mother or other old anger that has yet to be resolved. Establishing a good diet to improve and maintain better health would certainly be a major part of such a health-promoting plan of action. In addition, it can improve a person’s state of mind, as malnourishment can lead to depression and other emotional imbalances, not to mention muddled thinking.

Sorting out the various elements of how a person came to have problems with alcohol is something TA counselors have had a great deal of success with because so many of the issues involved, are basically reviewing all the elements of a person’s life that may need to be updated. In fact, most people, once they understand TA, go over a checklist every now and again to keep on target to make sure they are maximizing their lives based on constantly updated information.

Since discussions about Transactional Analysis, and how to use it to deal with alcohol issues can get complicated in a short column like ours, Elissa suggests that readers interested in learning more about it, might like to read two books by TA’s premier alcohol treatment expert, Claude Steiner. Even though written in the 1970’s they are

1, Games Alcoholics Play: The Analysis of Life Scripts – (Random House, 1974)
2, Healing Alcoholism – originally published by Grove Press in 1971 – Now available as a free download

A book that I recommend about the nutritional approach to alcoholism is Food and Behavior by Barbara Reed Stitt. Barbara was one of the first parole officers in the country who put her charges on a good diet and saved most of them from further jail time. Knowing that diet can change criminal behavior should give you some indication of the power of good nutrition. It should also prepare you for the following Treatment Protocol for Alcoholism from Dr. Abram Hoffer, who, along with Linus Pauling is the father of orthomolecular medicine.

We include the full press release of July 1, 2005 from the Orthomolecular News Service.

How to Practice Medicine Without A License

New Book: The Vitamin C Foundation's Co-Founder has written

Copyright 2008 by Owen Fonorow. Press ReleaseBook Web Site Forum Discussion... The book covers the fifty-plus year history of the vitamin C theory of heart disease as well as the 12-year history of the so-called Pauling-therapy®.

Heart patients who decided to follow Linus Pauling's advice recovered in about 30 days. Many experienced significant relief in as little as ten days. These recoveries only occur after these former patients adopted the Pauling-therapy®, usually without their doctor's knowledge or consent. The book contains Pauling's specific detailed vitamin C and lysine dosage recommendations.

These recommendations that have helped thousands of heart patients overcome their disease. The reasons that the therapy may not work for everyone are also explored. The book could have been appropriately titled Chronic Scurvy, which is a more accurate description of the cardiovascular disease process. Look for details [Here] when this First-ever Vitamin C Foundation Book becomes available.