Sunday, April 12, 2009

Alpha-lipoic acid reduces triglycerides in animal model of obesity/diabetes

An article published online on February 20, 2009 in the journal Archives of Biochemistry and Biophysics reported the benefits of the antioxidant compound alpha-lipoic acid in lowering triglycerides. High triglyceride levels often occur in obesity, and are a predictor of atherosclerosis, nonalcoholic fatty liver disease, and even premature mortality. Proper diet, exercise, and weight loss can help reduce triglycerides, but are not effective for everyone.

For the current research, Regis Moreau and colleagues at Oregon State University's Linus Pauling Institute used rats bred to become obese and diabetic. At five weeks of age, the animals were given 200 milligrams per kilogram body weight R-alpha-lipoic acid per day. Control rats were matched for food intake with the animals that received lipoic acid during the five week treatment period.
Not unexpectedly, triglyceride levels following meals were higher by the end of the study compared to pretreatment levels. However, while triglyceride levels doubled among those that received alpha-lipoic acid, they increased by over 400 percent in the control group. Continue Reading

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