For the first review, published in the February, 2008 issue of the European Journal of Clinical Nutrition, Pei-Yu Wang and colleagues selected 9 randomized, controlled trials which tested high isoflavone isolated soy protein or isoflavone tablets in a total of 432 perimenopausal or postmenopausal women.
Urinary deoxypyridinoline, a marker of bone resorption, and serum bone-specific alkaline phosphatase (BAP), a bone formation marker, were measured before and after the treatment periods, which ranged from 4 to 48 weeks.
The second meta-analysis, published in the February, 2008 issue of the journal Clinical Nutrition, included 10 trials involving 608 peri- or postmenopausal subjects who ingested soy products or isoflavones for 3 months to 4 years. Spine bone mineral density was measured by dual x-ray absorptiometry upon enrollment and at the end of the studies. Bone mineral content was determined in 6 of the trials. Continue Reading
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