Tuesday, September 9, 2008

Meta-analyses find soy isoflavones prevent bone resorption, stimulate bone formation and increase bone mineral density in menopausal women

The results of two meta-analyses conducted by a team from Peking University in Beijing, China and the University of Yamanashi in Japan have determined that not only does supplementing with soy help inhibit bone resorption and increase bone formation, it also improves spinal bone mineral density.

For the first review, published in the February, 2008 issue of the European Journal of Clinical Nutrition, Pei-Yu Wang and colleagues selected 9 randomized, controlled trials which tested high isoflavone isolated soy protein or isoflavone tablets in a total of 432 perimenopausal or postmenopausal women.
Urinary deoxypyridinoline, a marker of bone resorption, and serum bone-specific alkaline phosphatase (BAP), a bone formation marker, were measured before and after the treatment periods, which ranged from 4 to 48 weeks.
The second meta-analysis, published in the February, 2008 issue of the journal Clinical Nutrition, included 10 trials involving 608 peri- or postmenopausal subjects who ingested soy products or isoflavones for 3 months to 4 years. Spine bone mineral density was measured by dual x-ray absorptiometry upon enrollment and at the end of the studies. Bone mineral content was determined in 6 of the trials. Continue Reading

No comments: